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De Novo Design of G Protein Mimetics

De Novo Design of G Protein Mimetics

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Related Resources

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Biology by Design: Using High-throughput DNA Synthesis to Drive Biological Discovery

Biology by Design: Using High-throughput DNA Synthesis to Drive Biological Discovery

Twist High Throughput Antibody Production

Product Sheet Antibodies

The low-throughput, resource-intensive process of antibody variant characterization can be a costly bottleneck in the discovery pipeline. Twist High Throughput Antibody Production is a gene-to-protein workflow that relieves this bottleneck by producing tens to thousands of diverse antibodies for screening biophysical and pharmacokinetic properties. Twist’s silicon- based DNA synthesis platform can precisely write thousands of genes per run, enabling the rapid and high-throughput production of antibodies for discovery and screening.

Harnessing the diversity of CRISPR-Cas proteins for genome editing

The efficiency and ease of use of the CRISPR-Cas9 system has led to its rapid adoption as a robust and versatile genome editing tool. However, limitations remain - not least the constraint of the Cas9 protospacer adjacent motif (PAM), which limits the locations that can be targeted. One way to overcome this is to explore the natural variation afforded by other CRISPR-associated (Cas) enzymes - which provide a rich resource for the development of RNA-guided genome editing tools with diverse and potentially beneficial properties.

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