The Changing Landscape of CRISPR Screening

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The Changing Landscape of CRISPR Screening

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High-throughput evaluation of genome editing tools

Webinar Oligo Pools

Hear from Professor Hyongbum Henry Kim about his exciting research work around CRISPR and Prime editing. He will also take the opportunity to share more about Combining Massive Oligo Pools and Artificial Intelligence (AI) to Predict Guide RNA Efficiency for Prime Editing Screens.

Combining Massive Oligo Pools and AI to Predict Guide RNA Efficiency for Prime Editing Screens

Application Note Oligo Pools

A key challenge exists whenever a new CRISPR application is developed: How do you predict which guide RNA sequence will maximize the chance of an edit? Prime editing is one of the newest CRISPR technologies. It is highly promising as it can install small and precise mutations with a unique reverse transcriptase dependent mechanism that eliminates the need for donor DNA and double-strand breaks. Due to its precise editing capabilities, it has potential applications in CRISPR therapeutics for treating genetic disease.

Versatile High-Throughput Screening for Transcriptional Repressor Domains Using a Single 300mer Oligo Pool

Application Note Oligo Pools

The ability to generate 300mer oligos is a critical tool for researchers, enabling them to screen more than 70% of sequences identified in PFAM as human nuclear protein domains, which are potential effectors. Coupled with the exceptional precision, length, and uniformity of Twist Oligos, HT-recruit opens the door to protein domain characterization on a genome-wide scale.

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